PHILADELPHIA - An infield fly on a ball that landed in the outfield confused players and changed the game.

Alexi Amarista's safety squeeze in the seventh scored the go-ahead run and the San Diego Padres benefited from a strange double play to beat the Phillies 4-3 Monday in Philadelphia's home opener.

Wil Myers hit a solo homer for the Padres, who had two video reviews go their way.

The Phillies trailed 3-2 with the bases loaded and no outs in the sixth when pinch-hitter Darin Ruf lofted a high popup that was immediately ruled an infield fly. The ball kept carrying out to left field and drifted over shortstop Alexei Ramirez before it landed untouched in the outfield. Ramirez picked it up and threw to third base to force out Odubel Herrera with Cesar Hernandez scoring the tying run.

The Phillies challenged the out at third, but it was confirmed on replay. Ruf was out once third-base umpire Will Little signalled for the infield fly.

"I don't know if anybody knew what was going on. We might have gotten a break there," Padres manager Andy Green said.

Phillies manager Pete Mackanin obviously wasn't pleased with the call.

"Normally you wouldn't see that call on a ball that far out in the outfield," Mackanin said.

Herrera was still perplexed after the game.

"First time I see something like that," he said through an interpreter. "(Amarista) tagged me and I think was as confused as I was."

Crew chief Ted Barrett explained "the depth of the fly ball into the outfield" is not a factor on the call.

"It's actually (whether it can be) easily caught by an infielder, with ordinary effort," Barrett said in a pool report.

Said Ramirez: "It's the umpire's call, so it must be right."

Kevin Quackenbush (1-0) struck out the only batter he faced to earn the win after starter Andrew Cashner allowed three runs in five-plus innings. Fernando Rodney tossed the ninth for his first save for the Padres.

Philadelphia's Aaron Nola (0-2) allowed four runs and six hits, striking out a career-best nine in seven innings.

Derek Norris hit a one-out double off Nola in the seventh and advanced on Ramirez's infield single. Third baseman Maikel Franco made an outstanding diving grab but his throw pulled first baseman Ruf off the bag. The play was initially ruled an out, but the Padres challenged and won. Amarista then executed a perfect sacrifice to score Norris, who broke for home after the ball was bunted toward Nola.

Nola retired the first six batters on just 16 pitches before Ramirez led off the third inning with a single. Jon Jay's two-run double gave the Padres a 2-0 lead.

Myers connected to left leading off the fourth to make it 3-0.

Hernandez hit a triple and scored on Herrera's single for Philadelphia's first run. Peter Bourjos followed Cameron Rupp's double with a one-out RBI double to cut it to 3-2 in the fifth.

STANDINGS

Padres: Improved to 3-4 with their third win in four games after opening the season with three straight shutout losses against the Dodgers. "We're not going to get on a high just winning three of four," Green said.

Phillies: After winning two in a row against the defending NL champion Mets, Philadelphia fell to 2-5.

CORNER MAN

Brett Wallace started at first base for the Padres with Myers moving to left field for the first time this season. Wallace might get his next start across the diamond. He'll begin taking grounders at third base as San Diego looks to fill a void left by Yangervis Solarte's injury.

RESPECT

The Phillies held a moment of silence before the game for Philadelphia Flyers founder Ed Snider, who died Monday after a two-year battle with bladder cancer. He was 83.

THE CHAMPS WERE HERE

Members of the national champion Villanova Wildcats were at the game, including coach Jay Wright. Ryan Arcidiacono and Daniel Ochefu threw out the first pitch and some of their teammates joined the Phillie Phanatic atop the Phillies dugout after the seventh inning.

UP NEXT

Padres LHP Robbie Erlin (1-0, 0.00) opposes Phillies RHP Charlie Morton (0-1, 14.73). Erlin makes his first start after earning a win at Colorado by tossing 3 2-3 innings scoreless relief on Friday. Morton struggled in his debut with Philadelphia, allowing six runs in a loss at Cincinnati.