(SportsNetwork.com) - Jake Arrieta has put together a pretty impressive month of June for the Chicago Cubs.

Boston Red Sox hurler Jake Peavy can't say the same.

The two hurlers square off on Monday night in the opener of just the fourth all-time regular-season series between the two historic franchises.

Arrieta has yielded only four runs in five starts this month and has fanned 29 batters over his current three-start winning streak. That run will be put to the test on Monday as Arrieta is 0-3 lifetime versus the Red Sox with a 5.90 earned run average in six meetings, including five starts.

The right-handed Arrieta was in top form last Tuesday against the Cincinnati Reds, taking a perfect game into the seventh inning. He ended up allowing two runs in his final frame of work, striking out nine without a walk in the 7-3 triumph.

"I knew that's kind of what was going on from the get-go, most guys do when you're in a situation like that," Arrieta said of the perfect-game bid. "But I just wanted to continue to execute pitches and try and pitch deep in the game.

"That was the only couple of thoughts going through my head."

The 28-year-old improved to 4-1 with a 2.05 ERA on the season, while his counterpart Peavy comes in 1-6 on the year with a 4.93 ERA and without a victory since April 25.

Peavy is in danger of posting a second straight winless month as he lost his second start in a row and sixth consecutive decision after dropping an 8-2 decision in Seattle on Tuesday. The 33-year-old righty was tagged for a season-high seven runs on eight hits over five frames, giving up two homers.

One of those came in the fifth frame, a three-run shot by Seattle's Kyle Seager that highlighted a four-run frame for the Mariners and broke open a close game.

"I settled in and felt better. Then I got in trouble and made a bad pitch to Seager and the ballgame got away," said Peavy.

Peavy will try to get on track versus a Cubs franchise that he is 7-4 against lifetime with a 2.76 ERA in 14 meetings.

The Red Sox play the first of 10 in a row at home, while the Cubs are kicking off an 11-game road trip. Boston is 5-4 versus Chicago in the regular season dating back to 2005, winning a series at home in 2011 and then in Chicago the following year.

Though Boston took two of three from the New York Yankees over the weekend, the series win gave the club just a 4-6 road trip and at 38-44, the Red Sox reached the halfway mark of the season under .500 for the first time since 1997.

Boston slugger David Ortiz belted the 450th homer of his career in Sunday's 8-5 win and comes in hitting .310 in 13 previous games versus the Cubs with four homers and seven RBI.

The Cubs, meanwhile, enjoyed their first scheduled Sunday off since 1932 as they wrapped a four-game series with the Washington Nationals with a doubleheader on Saturday. The clubs moved up the finale of the series a day to help alleviate some expected traffic due to Sunday's Pride Parade.

Chicago took a split of the set with Washington, getting swept in Saturday's doubleheader, the first scheduled for the franchise since 1983, to go 4-6 on a 10-game homestand.