PHOENIX - Corey Kluber gave Cleveland a much-needed quality start, pitching seven effective innings to help the Indians beat the Arizona Diamondbacks 6-1 on Wednesday night to end a four-game losing streak.

The Indians ran through their bullpen in a 14-inning game the night before Kluber (7-5) gave them a lift with another strong interleague effort.

Michael Brantley homered and had two RBIs against Chase Anderson (5-3), sending the rookie to his third straight loss after opening his career with five consecutive wins.

Yan Gomes also homered for Cleveland and Michael Bourn had a pair of triples among his three hits.

Arizona had five hits and scored its lone run when Miguel Montero lined a run-scoring single with two outs in the ninth.

Both teams needed their starters to go deep into the game after Tuesday night's marathon.

Arizona won 9-8 on Aaron Hill's single in the 14th inning after both teams emptied their bullpens in a game that lasted 5 hours, 32 minutes, matching the longest game in Chase Field history.

Cleveland's bullpen had already been taxed before Tuesday's game — pitching 20 of the 41 1-3 innings in four games — so the Indians really needed a good outing from Kluber. And he delivered.

After giving up a pair of hits to start the first inning, Kluber limited Arizona's chances, allowing one runner to reach second base over the next six innings.

Kluber allowed four hits and struck out eight to improve to 6-0 with a 2.28 ERA in six career interleague starts. He also lined a single to left in the fourth inning for his first career hit.

Anderson ate up a few innings, though wasn't nearly as effective.

After losing his past two starts despite pitching well — four earned runs in 11 innings — the right-hander wasn't nearly as sharp against the Indians.

Anderson gave up a run in the first inning on Asdrubal Cabrera's sacrifice fly, and Gomes homered in the second. Brantley had a run-scoring groundout in the third inning and put Cleveland up 4-0 with a solo homer to right in the fifth.

Anderson allowed seven hits and walked three in five innings.

Jason Kipnis and Lonnie Chisenhall each had run-scoring hits off Zeke Spruill in the seventh inning to put the Indians up 6-0.

NOTES: Indians ace Justin Masterson will have his start on Sunday pushed back due to a sore right knee. He will be shut down for two days before throwing a bullpen to see how he's feeling. ... Arizona had stolen eight straight bases before Ender Inciarte was thrown out at third in the third inning. He was initially called safe, but it was overturned after a review. ... Arizona has a day off before RHP Brandon McCarthy pitches in a road game against San Diego on Friday. The Indians also have a day off before RHP Trevor Bauer starts the opener of a three-game series at Seattle.