SAN ANTONIO — The Spurs turned to their "grandpa" for the lift their young stars have struggled to provide in the past two games.

Manu Ginobili hit the court, literally, providing an early spark that helped carry San Antonio to a 116-103 victory over Memphis.

Kawhi Leonard had 28 points and the Spurs rebounded from two discouraging road losses to beat the Grizzlies on Tuesday night and take a 3-2 lead in their first-round series.

Ginobili had 10 points, three assists and three steals in 18 minutes. It was not an overly impressive stat line, but it was how the 39-year-old played that energized San Antonio.

In what could be the final season of his storied 15-year NBA career, Ginobili threw his body to the court and drove to the basket with the fearlessness he showed as a rookie.

"You know that he's got a huge heart, and he has a huge effect on our team when he's healthy," Spurs coach Gregg Popovich said. "And having a good night, starting out the way he did, was really a big boost."

After failing to score in the first four games, Ginobili had six points in 33 seconds in the first quarter. He hit the court face-first after stealing the ball and getting tangled up with Vince Carter to preserve a lead at halftime.

"He brought that grandpa juice is what I call it and we all followed," Patty Mills said. "We shouldn't wait for him to do that before we get into gear, but it really is inspiring when you see him dive on the ball putting his body on the line. Hard drives, hard cuts, it gets us all going."

With each team winning on its homecourt, Game 6 is Thursday night in Memphis.

"We expected it to be a long series," said Grizzlies point guard Mike Conley, who had a team-high 26 points. "Every game, including tonight, is a Game 7 in our opinion, we're treating every game like it's the last game. We expect to come back here (Saturday for Game 7). That's our mindset."

Marc Gasol added 17 points for Memphis, which has lost nine straight post-season games in San Antonio.

Tony Parker added 16 points and six assists and LaMarcus Aldridge had 12 points and nine rebounds for the Spurs.

Ginobili's play was especially inspiring to his best friend on the team, Mills, who scored a post-season-high 20 points on 5-for-7 shooting.

"He was incredible, he finished the game," Ginobili said. "He made four 3s in the fourth, tough ones, quick release. Sometimes you need something like that from somebody. Sometimes it's going to be him, sometimes it's Kawhi, more often. It's good to have a team that deep."

The Spurs shot 14 for 28 on 3-point attempts, two off its post-season record.

"They're the same shots that we shot in the first three, four games, they just dropped tonight," Mills said. "But definitely a good feeling when you can see some go in."

San Antonio shot 53 per cent from the field and Memphis shot 52 per cent in a surprisingly explosive game between teams renowned for their defence.

"We were definitely sharper with our defensive execution at home," Grizzlies coach David Fizdale said. "No doubt about it. It was night and day. The mistakes, just mindless mistakes today. A lot of their baskets came off breakdowns."

James Ennis III had 11 points and Andrew Harrison added nine, as both took advantage of Leonard leaving them to help defensively during the second and third quarters.

TIP-INS

Grizzlies: Conley and Gasol are the only Memphis players to score in double figures in all four games. ... Zach Randolph had nine points and six rebounds Tuesday after averaging 17 points and 9.7 rebounds in the previous three games. Randolph was held to six points and three rebounds in Game 1. ... Tony Allen remained out with an injury to his right leg after being kicked in the calf during Memphis' regular-season finale against Dallas. ... Ennis was 4 for 9 from the field in scoring 11 points after averaging 7.0 points in the previous four games.

Spurs: San Antonio's franchise record for 3-pointers made is 16 against Miami in the 2013 NBA Finals. ... Leonard has scored in double figures in 25 straight playoff games, the longest streak in franchise history since Tim Duncan had 26 from 2011-2013. ... The Spurs have lost three straight only once this season, dropping their final three games of the regular season after clinching the second seed. They have lost two straight on four occasions, including back-to-back losses in Memphis in this series. ... Dewayne Dedmon returned after missing Game 4 due to an illness. ... Ginobili's eight points in the opening quarter are the most he scored in any quarter of a playoff game since scoring nine in the 2014 NBA Finals.

FATHER TIME

Ginobili said he has definitely felt his age this season.

"Yeah, when your try to go by somebody and you can't go by anybody, it's when you start to feel it more," he said. "Many guys my age are in pain, back problems, knee problems, I don't have any of that. I'm very lucky in that regard, I'm not playing with pain. I'm slow, you lose a lot of explosiveness, that's normal. I'm not in pain and that's one of the things that stretched my career."

NOT THIS TIME

Before the game, Fizdale made his first appearance at the podium in San Antonio since delivering a nearly 2-minute diatribe on the officiating in Game 2 on April 17. Fizdale punctuated his tirade by slamming the table, but refrained from doing so during his pre-game session Tuesday.

"No, no, no," Fizdale said, rising quickly as he chuckled. "That costs too much money."

The NBA fined Fizdale $30,000 for his tirade.