| Josh Reddick | RF | 5/7/2013 | on 15-day DL | Sprained right wrist |
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| Brett Anderson | P | 5/1/2013 | on 15-day DL | Right foot stress fracture |
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| Scott Sizemore | 2B | 4/10/2013 | on 60-day DL | Torn left ACL - out for season |
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| Hiroyuki Nakajima | SS | 3/27/2013 | on 15-day DL | Strained left hamstring |
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| Fernando Rodriguez | P | 3/23/2013 | on 60-day DL | Right elbow surgery - out for season |
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