| J.A. Happ | P | 9/4/2012 | on 60-day DL | Fractured right foot |
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| Luis Perez | P | 7/12/2012 | on 60-day DL | Torn ligament in left elbow |
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| Drew Hutchison | P | 6/16/2012 | on 60-day DL | Right UCL sprain |
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| Kyle Drabek | P | 6/14/2012 | on 60-day DL | Torn right elbow ligament |
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| Sergio Santos | P | 4/21/2012 | on 60-day DL | Right shoulder inflammation |
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| Dustin McGowan | P | 3/26/2012 | on 60-day DL | Plantar fasciitis, right foot |
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