| Chris Withrow | P | 9/1/2012 | on 60-day DL | Recovery from torn pectoral muscle |
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| Alfredo Silverio | LF | 8/31/2012 | on 60-day DL | Recovery from auto accident, concussion |
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| Chad Billingsley | P | 8/25/2012 | on 60-day DL | Right elbow pain |
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| Jerry Hairston Jr. | 2B | 8/12/2012 | on 60-day DL | Left hip inflammation |
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| Todd Coffey | P | 7/3/2012 | on 60-day DL | Right elbow soreness |
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| Ted Lilly | P | 5/24/2012 | on 60-day DL | Left shoulder inflammation |
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| Justin Sellers | SS | 5/23/2012 | on 60-day DL | Bulging disc in lower back |
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