BOSTON - David Ortiz hit his 492nd career homer, Jackie Bradley Jr. and Ryan Hanigan connected on consecutive pitches, and Joe Kelly went six strong innings to lead the Boston Red Sox to a 6-4 win over the Cleveland Indians on Wednesday night.

Travis Shaw also homered following Ortiz's solo shot for the Red Sox, who have won four of six.

The victory came a day after the Red Sox shook up their front office, hiring Dave Dombrowski as president of baseball operations.

Boston's homers all came off Corey Kluber (8-13), last season's AL Cy Young Award winner.

Yan Gomes hit a three-run shot for the Indians, who have lost four of five.

Kelly (6-6) gave up one unearned run on five hits, striking out three and walking three to win his fourth straight start. Junichi Tazawa worked the ninth for his first save.