MILAN — More than 16 years after his father scuppered Juventus' title hopes, Giovanni Simeone has halted the Bianconeri's charge to a sixth successive Serie A title.

Simeone scored two goals to set Genoa on its way to a surprise 3-1 win over Juventus on Sunday.

"Three days ago my father told me that scoring goals was in a Simeone's blood," the 21-year-old Simeone said. "I am happy at the moment, when the coach gives a player the chance, he has to be ready."

Juventus remained four points ahead of Roma and AC Milan, which won 4-1 at Empoli on Saturday.

"There are no excuses for how we played in the first half hour," Juventus coach Massimiliano Allegri said. "Today it was right to get a good hiding, it will serve us well for the rest of the season."

It was a far cry from Juventus' midweek performance when it won 3-1 at Sevilla to secure qualification to the Champions League knockout stages.

"We have lost three matches, all of them after Champions League games, maybe unconsciously the players relaxed a bit," Allegri said. "It shouldn't happen but it happens and we have to take the positives: Get our feet back on the ground and understand that the season is still long and nothing should be taken for granted."

Current Atletico Madrid coach Diego Simeone fired Lazio to a 1-0 win against Juventus in April 2000, with the capital club going on to finish a point above the Bianconeri to win the title.

And 6,084 days later his son Giovanni Simeone got Genoa off to the best start with his first goal in the third minute. An error from Leonardo Bonucci sparked a Genoa counterattack and, although Gianluigi Buffon made three reaction saves, he couldn't prevent Simeone tapping in from close range.

Simeone doubled his tally 10 minutes later with a diving header to Darko Lazovic's cross.

Incredibly Juventus was 3-0 down on the half hour. A corner came to Luca Rigoni and Alex Sandro tried to keep out his volley but only succeeded in turning it into his own net.

Juventus hadn't conceded three goals in the first half of a Serie A match for more than 11 years.

Matters grew worse for Allegri's team as Bonucci limped off with a suspected hamstring injury moments later and was replaced by Daniele Rugani. Juventus was already without its two other regular defenders, with Andrea Barzagli injured and Giorgio Chiellini only fit for a place on the bench.

Gonzalo Higuain came on for Stephan Lichtsteiner in the 53rd but couldn't help Juventus turn the match around. Any hope it had of doing so diminished in the 75th when Dani Alves was stretchered off after fracturing his left leg and it was forced to play the final 15 minutes with 10 men because Allegri had used up his three substitutions.

Miralem Pjanic scored a consolation for Juventus eight minutes from time, curling a free kick into the top left corner.

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ROMA 3, PESCARA 2

Serie A top goalscorer Edin Dzeko was on target again — twice — as Roma survived a late scare to move to within four points of Juventus.

Dzeko appeared to have set Roma on its way to a comfortable victory with two goals in the opening 10 minutes but Ledian Memushaj pulled one back on the hour mark.

Diego Perotti restored Roma's two-goal advantage in the 71st with a penalty after he was needlessly brought down near the byline by Pescara defender Alessandro Crescenzi — who is on loan from the capital club.

Crescenzi made up for his error minutes later with a cross from the left which Roma defender Emerson headed away. The ball was then volleyed in by an unmarked Gianluca Caprari, who progressed through the ranks at Roma and made his Serie A debut with the capital club.

The 40-year-old Francesco Totti, who is only months younger than Pescara coach Massimo Oddo, was brought on in the second half. He almost scored directly from a corner but Pescara goalkeeper Albano Bizzarri saved at the near post.

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PALERMO 0, LAZIO 1

Palermo fell to a club record seventh successive Serie A defeat as Lazio continued its push for a Champions League place.

Sergej Milinkovic-Savic scored the only goal of the match, shortly after the half hour, tapping in after Dusan Basta pulled the ball back from the byline.

Ciro Immobile had earlier hit the crossbar.

Palermo defender Giancarlo Gonzalez was sent off in the final minutes for hauling down Cristiano Lombardi.

Lazio remained fourth, a point behind Milan and Roma. It plays Roma next week in the capital derby.

Palermo, which has lost all seven home games this season, slipped to bottom place, four points from safety.

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OTHER MATCHES

Atalanta remained level with Lazio after easing to a 2-0 win at Bologna.

Andrea Masiello fired Atalanta in front in the 15th and Jasmin Kurtic headed in a corner for the second in the 68th.

Crotone drew 1-1 against Sampdoria to move off bottom spot and Cagliari beat Udinese 2-1.

Napoli hosts Sassuolo on Monday, when Fiorentina travels to Inter Milan.