PSV Eindhoven's dismal season reached a new low on Thursday by losing 1-0 at home to Chornomorets Odesa to become the biggest name to crash out of the Europa League.
However, English Premier League side Swansea survived a defeat to St. Gallen to advance to the last 32, joining Chornomorets, NK Maribor and Maccabi Tel Aviv in reaching the knockout stage after the final round of group matches.
Two more places were up for grabs in the late kickoffs, with Dynamo Kyiv needing at least a draw against Rapid Vienna to progress from Group G.
PSV is a former European champion and winner of the UEFA Cup -- the pre-cursor to the Europa League -- but has fallen on hard times and is languishing in 10th place in the Netherlands' Eredivisie after Saturday's 6-2 humbling by Vitesse Arnhem.
Phillip Cocu's side has also exited the Dutch Cup and is now out of Europe thanks to Franck Dja Djedje's 59th-minute goal for Chornomorets, which plays in Ukraine. PSV is without a victory in more than two months.
Chornomorets qualified from Group B with Ludogorets Razgrad.
Swansea lost 1-0 at St. Gallen, with Marco Mathys scoring the winner, but advanced as the runner-up in Group A because Kuban Krasnodar only drew 1-1 at Valencia, which had already sealed top spot.
England will have two teams in the last 32 because Tottenham has already qualified, but Wigan failed to join them after losing 2-1 at Maribor, which climbed to second place in Group D above Zulte Wagerem on goal difference. Zulte lost 2-0 at home to Rubin Kazan.
Maccabi Tel Aviv sealed runner-up spot in Group F courtesy of a 1-0 home win over Bordeaux.
Fiorentina went through as the unbeaten Group F winner after a 2-1 win against FC Dnipro.
Juventus, Ajax, Benfica, Napoli, Porto, Shakhtar Donetsk, Viktoria Plzen and Basel dropped down into the Europa League after finishing third in their Champions League groups. The draw for the 32 takes place on Monday.