BERLIN -- Injury-hit Augsburg ended Bayern Munich's record 53-game unbeaten run in the Bundesliga with a 1-0 victory Saturday and Borussia Dortmund came from behind to beat Wolfsburg 2-1.
Sascha Moelders scored in the 31st minute for Augsburg to hand Bayern its first league loss since a 2-1 defeat at home to Bayer Leverkusen on Oct. 28, 2012.
"That's football, that's sport," Bayern coach Pep Guardiola said. "You can't always win. There was going to be a loss sooner or later."
It was Augsburg's first victory over its larger Bavarian rival after five league and three German Cup defeats, and Bayern's third successive game without a win in all competitions since it won the Bundesliga title with seven games to spare.
Guardiola's side drew 3-3 against Hoffenheim last weekend and then 1-1 at Manchester United in the Champions league quarterfinal first leg on Tuesday.
With one eye on next Wednesday's return leg, the Spaniard fielded a weakened side in Augsburg, with seven changes to the side that lined up in Manchester.
Arjen Robben, Franck Ribery and Philipp Lahm were left out of the squad, while David Alaba, Jerome Boateng, Mario Goetze, Dante and Thomas Mueller all started on the bench.
"The Bundesliga is over for us. Our target is the Champions League," Guardiola said in the run-up to the game, before opting to give Mitchel Weiser, Pierre-Emil Hojbjerg and Ylli Sallahi their starting debuts.
Deputy goalkeeper Tom Starke was also supposed to start but he tore a ligament in his right elbow in training on Friday.
A mistake from Weiser led to the goal. The Bayern midfielder was easily dispossessed by Daniel Baier, who set Moelders through on goal in front of Manuel Neuer. The Augsburg striker fired hard and high to give the Bayern No. 1 little chance.
The lead was deserved, with Bayern unusually passive and disorientated in the face of the home side's harrying and quick passing game in the first half.
"The lead was super for us. We could be more compact and rely on the counterattack then," said Augsburg coach Markus Weinzierl, who missed three injured regulars and suspended top-scorer Andre Hahn. "It all went very well."
Neuer denied Alexander Esswein in the 52nd, and though Bayern improved -- David Alaba's effort crashed back off the post in the 68th -- Augsburg managed to hold on, and even struck the post through Moelders in the 89th.
"We accept it and now we have to prepare as quickly as possible for the Manchester game," Guardiola said. "Next Wednesday we have a final. It's about life or death."
Marco Reus scored one and set up another for Dortmund in the late game, denying Wolfsburg the chance to go fourth.
Ivica Olic fired the visitors ahead on a rebound in the 34th, and might have scored again six minutes later, when he struck the crossbar and then hit it again with the rebound from his first attempt.
Robert Lewandowski equalized in the 51st with a header from Reus' corner, and a mistake from Wolfsburg keeper Max Grun on his 27th birthday, when he dropped the ball after colliding with a defender, allowed Reus to swoop for the winning goal in the 77th.
Dortmund next hosts Real Madrid in the Champions League on Tuesday, when it hopes to overturn a 3-0 away defeat.
"I haven't given up in any case," Reus said. "Nothing is impossible in football."
The result meant Borussia Moenchengladbach stayed fourth on goal difference from Bayer Leverkusen after a 2-0 win at relegation-threatened Nuremberg.
Juan Arango scored with a deflected free kick that gave Nuremberg 'keeper Raphael Schaefer no chance in the 18th, and Max Kruse made sure of the result with a penalty in the 79th.
"It was close, but the result is not undeserved," Moenchengladbach coach Lucien Favre said.
Also Saturday, Schalke drew 1-1 at Werder Bremen, Stuttgart beat fellow relegation candidate Freiburg 2-0, and Eintracht Frankfurt defeated Mainz 2-0.
Bremen striker Franco Di Santo scored from a narrow angle in the 15th minute, but Leon Goretzka equalized in the 33rd for Schalke.
Ibrahima Traore did brilliantly to create Stuttgart's breakthrough in the 69th, eluding three defenders on the right and playing a one-two with Christian Gentner before crossing for Maxim Alexandru to score.
Martin Harnik sealed the win in the 89th, as Stuttgart climbed above Hamburger SV on goal difference and out of the relegation zone.
"It's only a little step," Stuttgart coach Huub Stevens said.
Goals from Joselu in the 52nd and Alexander Meier in the 85th were enough for Frankfurt.
Leverkusen earlier sacked Sami Hyypia as coach with Champions League qualification anything but assured.