Both players suffered high ankle sprains in last week's loss to Tampa Bay and have been wearing walking boots since then.
Coach Dennis Allen had been hopeful of getting at least one of the two back in time to play the Ravens. Now the Raiders will have to lean on a seldom-used third-string running back and a converted fullback to get the running game going.
"(Neither) of them made enough progress this week that they were able to be up," Allen said Friday. "We'll probably be going through the same thing next week and we'll see where we're at."
This marks the 14th game in five seasons McFadden has missed because of injuries. The fourth overall pick in 2008, he has yet to play a full 16-game schedule since entering the NFL.
McFadden was injured early in the first quarter against the Buccaneers when his left ankle bent awkwardly following a short gain. He remained in the game and continued to play before leaving for good with about nine minutes left in the first half.
Taiwan Jones, a fourth-round pick in 2011 who has played primarily on special teams this season, and fullback Marcel Reece have been splitting reps in practice with Oakland's first team offence while McFadden and Goodson are sidelined. The team has also discussed the possibility of activating former Stanford running back Jeremy Stewart from the practice squad.
"Of course I'm very excited," Jones said. "You've gotta be patient in this league. I've been waiting for my opportunity and it's here, so I'm going to try to make the most of it."
Jones, who sat out the final six games of 2011 with a hamstring injury, has only one carry for two yards this year. He began the season as the Raiders kickoff returner but fumbled in his first play of the opener against San Diego.
Since then, Jones has seen very little playing time in the backfield but has emerged as Oakland's leading tackler on special teams.
Now that he's back on offence, the speedy Jones will pair with Reece in an attempt to spark a running game that ranks 31st in the NFL.
"I'm very aware that I'm not Darren McFadden," Jones said. "The coaches, they do a good job of putting me in positions and giving me plays for what I can bring to the table. I'm not trying to be Darren McFadden or anyone else."
Defensive tackle Richard Seymour (knee, hamstring) will also miss the game. Desmond Bryant, who was pulled from last week's loss to Tampa Bay because of an irregular heartbeat, will start in Seymour's place.
Notes: Stewart, an undrafted free agent who scored nine touchdowns during his senior season at Stanford in 2011, will accompany the team on the trip to Baltimore but a decision on his status probably won't be made until game time. ... Allen said he expects to activate cornerback Ron Bartell from the temporary injured reserve list before Sunday's game. Bartell, who has been out with a shoulder injury he suffered in Week 1, will start if he's added to the 53-man roster. ... While the rest of his teammates were preparing for the short bus trip to the Oakland airport, WR Darrius Heyward-Bey went out to the practice field to catch passes from a Juggs machine. After leading the team in receptions a year ago, the former first-round pick has just 19 catches this season.