Wimbledon, England (Sports Network) - Serena Williams will not be a repeat champion at Wimbledon after she was a stunning fourth-round loser against German Sabine Lisicki on Monday at The Championships.
The 23rd-seeded Lisicki took down the world No. 1 superstar 6-2, 1-6, 6-4 on the famed Centre Court at the All England Club.
Williams was riding a career-best 34-match winning streak, which included Wimbledon, U.S. Open and French Open titles. She also captured an Olympic gold medal here at the All England Club last year.
The big-serving Lisicki is now 6-4 lifetime against top-10 women at Wimbledon.
Lisicki overcame a 3-0 deficit in the third set to oust the five-time Wimbledon champion Williams, who is a 16-time Grand Slam singles titlist who had won three of the previous four Wimbledon championships.
The 23-year-old Lisicki stunningly broke Williams for a 5-4 lead in the final set when the American great misfired long with a backhand.
Serving for the match, Lisicki failed on a first match point when she sent a forehand long, but she got another shot at a match point when Williams netted a forehand return.
Lisicki converted on that second match point with a forehand winner into a wide-open court, which marked her fifth break of Williams in the see-saw affair.
The match ended in 2 hours, 4 minutes, as the German smacked 10 aces, compared to seven for Williams, as both players broke serve five times.
"I didn't play the big points good enough," Williams said. "I didn't do what I do best.
"I think Sabine played really well," Williams added. "There's huge room for improvement for me."
When asked is Lisicki was reading her serve well on Monday, Williams said: "Yeah, I felt like she was just on today."
Lisicki is now 1-2 lifetime against the 31-year-old Williams. This was their first-ever meeting on the German's favorite surface, grass.
Williams topped Poland's Agnieszka Radwanska in last year's finale at the AEC.
The Williams loss means that a member of the "Big Three" -- Williams, Victoria Azarenka and Maria Sharapova -- will not win a major event for the first time since the 2011 U.S. Open. One of the three woman had won the last six Slams. Azarenka pulled out of her second-round match because of a knee injury last week, while Sharapova was shocked by Portugal's Michelle Larcher de Brito in the second round on the same day as Azarenka's pull out.
In other fourth-round action involving top-eight seeds, No. 6 Li Na of China whipped 11th-seeded Italian Roberta Vinci 6-2, 6-0 and No. 8 Czech Petra Kvitova handled 19th-seeded Spaniard Carla Suarez Navarro 7-6 (7-5), 6-3. Li was this year's Australian Open runner-up to Azarenka and is a former French Open champ. The quality left-hander Kvitova captured her lone Grand Slam title here at the All England Club two years ago by beating Sharapova in the final.
Also on Day 7, 20th-seeded Belgian Kirsten Flipkens bested Italian Flavia Pennetta 7-6 (7-2), 6-3 and capable Estonian Kaia Kanepi knocked out left- handed heavy British favorite Laura Robson 7-6 (8-6), 7-5. Flipkens will face Kvitova in the quarterfinals, while Kanepi will battle Lisicki in the round of eight.