Coach Bruce Arians says Colledge had nerve irritation in his right leg, which he called "good news" because the MRI showed no fracture.
Colledge, moved to the right side of the line in the off-season with first-round draft pick Jonathan Cooper at left guard, missed the first day of training camp for the birth of his daughter. He was hurt in a run-blocking drill Sunday.
"There is no timetable on his return," Arians said. "As soon as the nerve re-heals, he'll be back full speed."
Paul Fanaika moves in to the left guard spot with the first unit in Colledge's absence.
Williams' surgically-repaired right knee flared up and he was unable to get through Sunday's practice. Williams termed it a minor setback and an MRI showed no structural damage.
"I got it cleaned out in January so I'm still kind of dealing with some kinks to work out," Williams said on Monday. "Coming out here after a week off, pounding extra hard like I've been, it's just a little irritation, so we're taking some precautionary actions."
Williams said he's "pretty sure" there is no significant problem, but he is seeking a second doctor's opinion.
"I've been through this before and I just want to make sure nothing's wrong with it," he said.
Williams has played in just five games in his two NFL seasons after Arizona drafted him in the second round out of Virginia Tech in 2011. He missed his entire rookie season with a ruptured patella tendon in his right knee, then went down with a season-ending shoulder injury in week five a year ago.
Asked if this is a make-or-break year for the young running back, Arians said, "I would think so."
"It's just bad luck," Arians said. "He's been doing extremely well and tried to go through yesterday (Sunday). He went through the running backs vs. linebackers and just didn't feel he could push off on it."
Williams said he appreciates the support of the trainers and coaches as he works his way back. He knows he has to prove himself.
"The biggest thing is game time to go out there and show people I'm capable of doing things that they know I can do and that they brought me here to do," he said. "It's the most important thing right now because if I can't prove that I can stay healthy I might not be here."