Ware suffered a strained right quadriceps after pulling up lame as he rushed Redskins quarterback Robert Griffin III in the second quarter of Sunday's 31-16 win over Washington. Ware walked off the field and was examined on the sidelines before heading to the locker room.
Ware has never missed a game in his NFL career.
Murray suffered an MCL sprain in left knee early in the second quarter Sunday. Murray sustained the injury on a rush around the right edge. He finished with seven rushes for 29 yards and a touchdown.
Neither player practiced all week.
In addition, wide receivers Miles Austin (hamstring) and Dwayne Harris (hip) are probable, as are defensive linemen Jason Hatcher (neck) and George Selvie (shoulder). Running back Lance Dunbar (hamstring) and defensive end Edgar Jones (groin) are out.