TORONTO - Blue Jays starter Drew Hutchison was looking to have a clean sixth inning after his team rallied to tie the game in the bottom of the fifth.

But Orioles first baseman Chris Davis had other plans.

Davis hit a two-run home run to give Baltimore its second two-run lead of the night and Matt Wieters followed with a solo shot to help the visitors to a 10-2 win on Friday.

"I just made some bad pitches," said Hutchison, who lost at home for just the second time this season. "Thought I was throwing the ball real well through the first five. I was able to have a quick inning there in the fifth, we were able to tie it up in the bottom of the fifth and you need to go out there and have a shutdown inning."

Baltimore (65-69) has won three straight meetings between the two clubs.

The loss was the Blue Jays' (76-58) first defeat by more than three runs since July 4, when they fell 8-3 to the Detroit Tigers.

The Jays loss, coupled with the Yankees' 5-2 win over Tampa Bay, cut Toronto's lead in the American League East division to a half game.

Ubaldo Jimenez (10-9) went 5 2/3 innings, allowing one earned run on four hits while walking six and striking out four.

"I think the first couple of innings I was thinking a little bit too much that I couldn't make too many mistakes because of the way we've been hitting," said Jimenez. "The sinker was very good. I was getting on top of the ball and executing the pitch.

"It wasn't perfect (but) it was good start."

Hutchison (13-3) allowed six earned runs on nine hits and struck out two in five-plus innings of work. It was his first home loss since May 20.

Josh Donaldson had a sacrifice fly for the Blue Jays.

Adam Jones also hit a home run for the Orioles.

Tied 2-2 in the sixth, Davis took Hutchison deep to left with the two-run shot, his second home run of the game and league-leading 40th of the season. Wieters' solo homer, which bounced off the glove of Blue Jays left-fielder Ben Revere before clearing the wall.

"He got hit around," Blue Jays manager John Gibbons said of Hutchison. "He was throwing fine and then it happened fast … five or six pitches, they did all their damage. Then we gave it up late too, they opened it up. But he was throwing fine. … it happened fast."

After allowing five straight Baltimore hits in the sixth, Hutchison was replaced by Liam Hendriks. Jonathan Schoop gave the Orioles a 6-2 lead, scoring on a sacrifice fly from Manny Machado.

The Orioles added to their lead in the eighth. Gerardo Parra doubled off Bo Schultz to score a pair. Jones' two-run home run gave Baltimore a 10-2 lead.

Baltimore got on the board in the second when Davis led off with a solo shot to the second deck. Five batters later, third baseman Ryan Flaherty's RBI double gave the Orioles a 2-0 lead.

The Blue Jays cut into Baltimore's lead in the bottom half of the second inning as Chris Colabello scored on an error. Toronto tied the game 2-2 when Ryan Goins scored on Donaldson's sac fly in the fifth inning.

Notes: Blue Jays RHP Marcus Stroman threw a bullpen session pre-game as part of his rehab assignment. … Toronto LHP David Price gets the ball Saturday afternoon. The Orioles will counter with RHP Mike Wright.