Up 3-0 on aggregate from the away leg, Arsenal will not take any chances with a pair of players in Thursday's return leg at the Emirates.
Mesut Ozil and Aaron Ramsey will not dress when the Gunner welcome Ostersunds FK at the Emirates.
Germany international Ozil has been sick and Wales midfielder Ramsey has been dealing with a groin injury.
"There's still lots at stake," Arsenal manager Arsene Wenger said. "Ozil was in bed Monday and Tuesday. I would certainly have played him, but because he was sick he will have to work hard tomorrow and won't be involved."
The Europa League could be key to Arsenal's fortunes when it comes to their European ambitions next year. Wenger's side currently sits in sixth in the Premier League table, eight points behind Chelsea for fourth and the final Champions League place. Winning Europa League might be Arsenal's best chance to qualify for next year's Champions League as Manchester United did a year ago.
"We have to focus on the Premier League," Wenger said. "The Europa League is one of the priorities we have. But ideally we want to come back to the Champions League through the Premier League."
The Gunners are next in action after Tuesday's Europa League match in Sunday's League Cup final at Wembley against Manchester City.