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NFL: Lions 26, Panthers 32

Chuba Hubbard ran 20 times for a season-high 122 yards and two touchdowns, Bryce Young completed 29 of 41 passes for 329 yards and two touchdowns to Tetairoa McMillan and the Panthers overcame an injury-filled week to beat the Lions 32-26 on Sunday night.

NFL: Jaguars 22, Bengals 17

Trevor Lawrence passed for 227 yards and a touchdown, Jacksonville's defense forced two critical turnovers and the Jaguars held off the Cincinnati Bengals 22-17 on Sunday. Joe Burrow passed for 428 yards for the Bengals, who lost All-Pro wide receiver Ja'Marr Chase to a concussion in the second quarter.

Why was this such a frustrating loss for the Bills?

TSN Bills reporter Dave Naylor joins SportsCentre to break down why this loss to the Patriots is so frustrating for Buffalo, and why New England had to play this style of game to pull off the upset.

NFL: Patriots 29, Bills 26

Drake Maye threw three touchdown passes, including Efton Chism’s one-handed catch with 1:50 remaining, and the New England Patriots defeated the Buffalo Bills 29-26 on Sunday.

NFL: Jets 12, Bears 23

Kyle Monangai rushed for 146 yards and two touchdowns, and the Chicago Bears stuffed the New York Jets for a 23-12 victory on Sunday.

NFL: Dolphins 10, Vikings 15

The Minnesota Vikings stayed undefeated with more dominance by their defence and five field goals from Will Reichard, sidestepping their early passing game problems to secure a 15-10 victory over the winless Miami Dolphins on Sunday.

NFL: Colts 30, Commanders 13

Jonathan Taylor rushed for two touchdowns and Colts quarterback Daniel Jones ran one in and Indianapolis beat Washington after the Commanders lost yet another quarterback to injury on Sunday at Tottenham Hotspur Stadium.

NFL: Packers 17, Buccaneers 14

Jordan Love threw two touchdown passes and the Green Bay Packers overcame two fourth-quarter turnovers to beat the Tampa Bay Buccaneers 17-14 on Sunday.

NFL: Broncos 14, 49ers 24

Brock Purdy threw two touchdown passes and Christian McCaffrey ran for a score to lead the undefeated 49ers to a 24-14 victory over the Broncos on Sunday.

NFL: Cardinals 24, Giants 36

Jameis Winston threw three touchdown passes to offset a pair of interceptions, Deonte Banks had a 98-yard pick-6 in the final seconds and the New York Giants won another not-so-pretty game, defeating the Arizona Cardinals 36-24 on Sunday.

NFL: Titans 18, Ravens 24

Lamar Jackson threw for 222 yards and two touchdowns before leaving the game with an ankle injury, Derrick Henry scored against his former team, and the Baltimore Ravens handled the Tennessee Titans 24-18 on Sunday.

NFL: Rams 24, Eagles 20

Kyren Williams ran for two touchdowns in the final four minutes as Matthew Stafford and the Los Angeles Rams rallied from a 10-point deficit to beat the Philadelphia Eagles 24-20 on Sunday.

NFL: Chargers 23, Seahawks 30

Emanuel Wilson caught a touchdown pass and ran for another score and the Seahawks handed the Chargers a fourth straight loss to start the season with a 30-23 victory on Sunday. Sam Darnold threw for 168 yards and two touchdowns for the defending Super Bowl champions.

NFL: Chiefs 30, Raiders 27

Patrick Mahomes remained undefeated at Allegiant Stadium, passing for 225 yards and two touchdowns, and Kenneth Walker III rushed for 177 yards and two touchdowns to lead the Chiefs to a 30-27 victory over the Raiders on Sunday.

NFL: Cowboys 34, Texans 30

CeeDee Lamb had a career-high 17 catches for 189 yards and his 12-yard TD reception with 40 seconds left lifted the Dallas Cowboys to a 34-30 win over Houston on Sunday to keep the Texans winless.

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