New world champion Kimi Antonelli continued his strong form by topping the timesheets in the second practice session at the São Paulo Grand Prix.
Lando Norris, who set the pace in the first session, finished 0.253 seconds back from Antonelli in second.
Red Bull's Max Verstappen was third-fastest, with Mercedes George Russell in fourth.
Oscar Piastri in the other McLaren rounded out the top five.
Antonelli wrapped up the world championship last weekend at the Mexico City Grand Prix and became the youngest-ever to do so.
Russell has been hit with a five-place grid penalty after his Mercedes team fitted another new engine to his car for this weekend.
The team could win the constructors' championship at Interlagos if they outscore Ferrari by three points.
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McLaren have brought a significant upgrade package to Brazil, in a bid to end the season strongly and put its car in a positive place for the start of next year.
Lewis Hamilton and Charles Leclerc were off the pace and finished the session in sixth and seventh, respectively.
Interlagos usually brings extreme weather, with potential for storms disrupting Saturday's qualifying and Sunday's race, and the mist rolled in as practice drew to a close.
Information from PA contributed to this report.