Week 6 of the NFL Season has arrived, and we are back with another set of Best Bets from our TSN Betting team.
If you’re looking for more plays, check out Domenic Padula’s Week 6 Playbook for all of TSN’s lead sports betting analysts’ plays for the day.
Let’s get to the action. Here are our team’s best bets.
Domenic Padula: Rico Dowdle over 15.5 receiving yards
We know that Dowdle is motivated to face his former team for the first time. While the Cowboys have buckled down against opposing running backs on the ground, they have also allowed the most receiving yards to running backs this NFL season. Dowdle just had three catches for 28 yards in last week’s win over Miami. He should pick up where he left off with another strong performance as a pass catcher against Dallas.
Drew Morrison: Tyquan Thornton Over 16.5 longest reception
His props suggest he’s the fifth option in Kansas City’s offence, but Tyquan Thornton leads the team in receiving yards this season. In four of his five games, he’s had a 30-plus yard reception and more than doubled his pregame yards prop. He had a season-high 90 yards in last week’s loss. The Lions offence is electric, and I expect Andy Reid’s plan involves having to score a lot of points. On defence, Detroit’s front seven is healthy and stout against the run. In the secondary is a different story. The Lions will be without their starting cornerbacks for the foreseeable future, but according to the coaching staff, they’re still going to be giving the Chiefs a healthy dose of man coverage. Thornton’s route tree is one dimensional. He only goes deep. Patrick Mahomes will hit him for at least one against the Lions backup defensive backs.
Connor Ford: Jaylen Warren 3+ Receptions
I hope Aaron Rodgers is feeling well rested after the Steelers’ bye week because he’s up against a stingy Browns defence in Week 6. Cleveland is once again one of the best defences in the league – they rank tied for fourth in sacks (14) and first in Pass Rush Win Rate (54 per cent) this season. So, where will Rodgers go with the ball? My guess is Jaylen Warren.
The Steelers just don’t have many offensive weapons outside of DK Metcalf. That’s led to Rodgers targeting his running backs at nearly a 27 per cent rate this season. Warren has always been a factor in the passing game - he’s been targeted on 29.3 per cent of his routes this season, which ranks third among running backs with at least 10 targets. With Cleveland’s deadly pass rush on tap, I expect a lot of checkdowns from Rodgers.
Warren has had at least three catches in four of his last five meetings against the Browns. With two weeks off to get his knee right, I expect him to take back over as the lead guy in this Steelers backfield. I’ll lock in Warren 3+ receptions as my best bet for Week 6.
Luke Bellus: Marvin Harrison at least 50+ receiving yards
“It’s going to be a special game for me, for sure.”
Those were the words of Marvin Harrison Jr. earlier this week when asked about playing his first NFL game in the city where his father put together a Hall of Fame career.
Marvin Harrison spent 13 seasons playing for the Colts, winning a Super Bowl with the team in 2006 and was inducted into the team’s Ring of Honour in 2009, a day that Harrison Jr. was there for.
But today, while his father’s jersey hangs in the rafters above, the attention will turn to Harrison Jr. on the field with a former Colts QB leading the way.
Veteran QB Jacoby Brissett gets the spot start for Arizona today with Kyler Murray sidelined.
Last year, Brissett started the first five games of the season for the New England Patriots and leaned heavily on his top two options.
DeMario Douglas led Patriots’ wideouts with 24 targets in those games, six more than any other receiver on the team. Meanwhile, Hunter Henry’s 25 targets led the team and were 10 more than any other tight end.
So, with that in mind, I like Harrison Jr. and tight end Trey McBride to be fed early and often.
But with this being a homecoming for Harrison, I’m focusing my best bet on him.
The 23-year-old has also gone over this three times this season and now faces a Colts defence that has allowed the fifth most years per game to wide receivers in 2025.
