LONDON - Petra Kvitova let her lead slip, and let her title go.

Former top-ranked player Jelena Jankovic beat the defending Wimbledon champion 3-6, 7-5, 6-4 Saturday on Centre Court, coming back from a set and a break down to reach the fourth round at the All England Club for the first time since 2010.

Kvitova, who also won the title in 2011 and was seeded second this year, had an easy time in her first two rounds, losing only three games. And it looked like more of the same while leading 6-3, 4-2 until Jankovic started her comeback.

Jankovic, who finished 2008 at No. 1 in the rankings after playing in her only Grand Slam final at that year's U.S. Open, broke Kvitova to get back on serve at 4-4 in the second set, and then broke again to force a deciding set.

"Playing on grass is very difficult for me. It does not come natural," said Jankovic, a Serb seeded 28th at this year's tournament. "I just tried to stay one point at a time, just hang in there, stay positive and fight, and I made it."

Since reaching the fourth round in 2010, Jankovic had lost in the first round three times and made the second round in 2013.

For Kvitova, it was her earliest exit at Wimbledon since losing in the first round in 2009. Besides her two titles, she has also reached the semifinals and twice made the quarterfinals.

Also in the women's draw, fifth-seeded Caroline Wozniacki advanced to the fourth round by beating Camila Giorgi of Italy 6-2, 6-2 and No. 20 Garbine Muguruza of Spain defeated 2012 semifinalist Angelique Kerber 7-6 (12), 1-6, 6-2. Wozniacki will face Muguruza on Monday.

Other winners include No. 13 Agnieszka Radwanska, No. 15 Timea Bacsinszky, No. 21 Madison Keys, Olga Govortsova and Monica Niculescu.