The 3-1 Buffalo Bills are expected be without starting wide receiver Jordan Matthews until November.
According to Sal Capaccio of WGR 550, Matthews will undergo thumb surgery and miss a month of action as he recovers.
Matthews was injured in the Bills 23-17 win over the Atlanta Falcons on Sunday. He caught two passes for 10 yards and a touchdown before exiting.
The 25-year-old was acquired by the Bills from the Philadelphia Eagles in the preseason. He owns 10 receptions for 162 yards and a touchdown in four games with the team.
Matthews missed the three of the team's four preseason games due to a chest injury.
Also injured in Sunday's game was linebacker Ramon Humber.
The NFL Network's Ian Rapoport reports that the 30-year-old broke his hand and is also expected to miss an indeterminate amount of time.