Madrid, Spain - Canadian Eugenie Bouchard suffered yet another opening-round loss on Sunday, this time at the Madrid Open.

The sixth-seeded Bouchard had her match against Barbora Strycova in hand at 6-0, 3-1 before her Czech opponent roared back to claim a 0-6, 6-3, 6-3 victory.

The loss was the sixth straight for Bouchard, including her pair of losses at the Fed Cup last month in Montreal. The 21-year-old has not won a match since reaching the Round of 16 at the BNP Paribas Open in California in March.

The Madrid Open serves as a tune-up event for the French Open, which begins on May 24.

In other women's action Serena Williams and Maria Sharapova were among the first-round winners while second-seeded Simona Halep was shown a quick exit.

Williams, the top seed and Madrid champion in 2012 and 2013, needed just 55 minutes in a 6-0, 6-1 pounding of fellow American Madison Brengle, while the third-seeded Sharapova also had an easy opener with a 6-2, 6-3 triumph over Switzerland's Timea Bacsinszky.

France's Alize Cornet knocked off Halep in straight sets, 7-6 (8-6), 6-3, for the first major upset of this French Open tune-up.

Williams won the first set in 21 minutes, then grudgingly ceded a game to Brengle before quickly regaining focus. Brengle saved five break points in the first game of the second set.

"I was able to win good today, but she's been playing really well," Williams said. "I've been following her results. She got to the semifinals of her last clay-court event and she's been having some good wins."

Next up for Williams will be another fellow American in Sloane Stephens, who won her first-round match on Saturday in three sets against countrymate Bethanie Mattek-Sands.

Venus Williams was not as fortunate as her sister. She had a tough first-round match with Victoria Azarenka and the former world No. 1 from Belarus notched a 6-3, 7-5 victory. Azarenka could face Serena Williams in the third round.

Other seeded winners Sunday included 2011 champion Petra Kvitova and Caroline Wozniacki. The fourth-seeded Kvitova had to rally for a 3-6, 6-1, 6-4 win over qualifier Olga Govortsova of Belarus, while the fifth-seed Wozniacki made short work of Australia's Jarmila Gajdosova, 6-3, 6-0.

Former U.S. Open champ Samantha Stosur of Australia took out the 12th-seeded Angelique Kerber, 4-6, 6-3, 6-3.

Carla Suarez Navarro of Spain, Germany's Andrea Petkovic, Karolina Pliskova of the Czech Republic and Italy's Sara Errani were other seeded winners.

The 10th-seeded Suarez Navarro topped Zarina Diyas, 6-4, 6-4, the 11th-seeded Petkovic edged Italy's Flavia Pennetta, 6-3, 7-5 and the 14th-seeded Pliskova, coming off a title Saturday in Prague, blasted Spain's Silvia Soler Espinoza, 6-1, 6-2. Errani, the 15th seed, had won the first three games of her match against Paula Badosa Gibert when the Spanish qualifier retired.

Elina Svitolina of the Ukraine followed up her Marrakech title from Saturday with a 6-0, 6-3 rout of Slovak veteran Daniela Hantuchova to earn a second- round matchup with Ana Ivanovic, a Saturday first-round winner.

Second-round play begins Monday with Serena Williams and Stephens set to open the night session. Daytime matches feature Wozniacki against American qualifier Christine McHale, a 6-3, 6-2 winner Sunday against Germany's Mona Barthel, and ninth-seeded Agnieszka Radwanska of Poland against Australia's Casey Dellacqua -- both of whom won Saturday.