Toronto Raptors coach Nick Nurse said centre Khem Birch suffered a broken nose against the Detroit Pistons on Friday.
Birch will head back to Toronto and undergo surgery.
Birch logged just over three minutes of action before exiting the game.
On the season, Birch is averaging 6.0 points and 5.4 rebounds in 22 appearances.
The Raptors fell 103-87 to the Pistons for their second straight loss.